"By Grabthar's Hammer, Questerians Unite!"
A group of washed up actors from a cancelled, low budget sci-fi show suddenly find themselves in way over their heads when an alien race with no concept of fiction enlists their help in facing a galactic threat.
Best Star Trek movie EVAR. Some movies just make you happy and this is one of mine. If I ever ran a Star Trek campaign, this is how I would do it. You could run it (semi-)straight as a proper NSEA crew with disposable redshirt. Or and this would even be more fun, as a troupe of washed out actors and conventioneers as they bumble their way through the galaxy aboard an alien built replica of the NSEA Protector.
This website is old, but has some great info, including an episode guide for the show.
Suggested Supplements: Ships of the NSEA. Aliens of the Galaxy, The Sarris Dominion, The QuestCon 2013 Handbook.